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: In both mice and humans, chronic stress was found to reprogram myeloid progenitor cells in the bone marrow. This leads to an increased production of monocytes that are more reactive to future threats.

: The study is lauded for its translational approach , showing consistent results across both animal models and human subjects, which adds high clinical relevance. 109595

: It also refers to a recent eLife reviewed preprint (109595) that uses fruit flies to model RVCL-S , a rare genetic disease affecting blood vessels in the brain and retina. : In both mice and humans, chronic stress

: The study identifies specific epigenetic changes—molecular "marks" on DNA—that alter how immune cells respond to inflammation even after the stressor is removed. : It also refers to a recent eLife

The identifier primarily refers to a significant scientific study published in Cell Reports titled "Chronic stress primes innate immune responses in mice and humans," which explores how long-term psychological stress impacts the immune system at a cellular level. Overview of Study 109595

The research investigated the "priming" effect of chronic stress on the innate immune system. Traditionally, chronic stress is viewed as purely immunosuppressive (weakening the immune system), but this review-worthy study highlights a more complex mechanism where stress prepares the immune system for a hyper-responsive state.

The methodology and findings of this study have been widely cited in the medical community for bridging the gap between psychology and physical pathology.