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A critical diagnostic marker. It is virtually absent in healthy adult livers but highly expressed in HCC. It promotes tumor growth by stimulating the Wnt and IGF signaling pathways.

The "solid" clinical takeaway is that these molecules are becoming primary targets for precision medicine: 27879.rar

Its role is complex. While high serum levels often correlate with poor prognosis and metastasis, it can also act as a protective factor against inflammation-driven tumorigenesis in early stages. A critical diagnostic marker

Proteoglycan 4 (PRG4) has shown potential in making current chemotherapy drugs (like sorafenib) more effective by interfering with cancer cell resistance. 27879.rar

Proteoglycans in Cancer: The Case of Hepatocellular Carcinoma (HCC)