Grey's Anatomy S16e16 — Must Read

Alex claims that while he still loves Jo , he cannot bear to let his children grow up without a father the way he did. He is now living on a farm in Kansas where Izzie works as a surgical oncologist. ⚡ Secondary Storylines

He expresses his gratitude for their mentorship over the years. The Big Reveal: Izzie Stevens and the Twins

Season 16, Episode 16 of Grey's Anatomy , titled serves as the official farewell to original cast member Justin Chambers , who played Dr. Alex Karev . The episode aired on March 5, 2020, and is one of the most controversial in the series' history due to how it handles Alex's departure. ✉️ The Core Format: Letters from Alex Grey's Anatomy s16e16

While calling former colleagues to gather support for Meredith’s medical license hearing (earlier in the season), Alex reached out to Izzie .

After reading the letter and realizing her marriage is over, Jo heads back to work, determined to stay strong despite the heartbreak. 🗣️ Fan and Critic Reaction Alex claims that while he still loves Jo

Izzie has five-year-old twins, Eli and Alexis , who are biologically Alex’s.

While the letters dominate the episode, a few other developments occur at Grey Sloan: The Big Reveal: Izzie Stevens and the Twins

He discovered that Izzie used the embryos they froze years ago when she had cancer.