Ninahd Apr 2026

"NINAHD" (often stylized as ) refers to Nanopore Identification of N-Acetylation by Hydroxylamine Deacetylation . It is a universal chemical sensing strategy published in ACS Sensors in March 2024 to identify N-acetyl modifications on various biomacromolecules. Overview of NINAHD

: It can be used for disease-related research, such as analyzing cellular RNA acetylation or detecting modifications in biological samples like histones. There is also potential for it to be adapted for portable point-of-care testing. Technical Components Hydroxylamine Reagent used for the selective deacetylation process. AHA (Acetohydroxamic acid) The chemical reporter produced during the reaction. PBA-modified MspA The specific nanopore sensor engineered to detect AHA. NinaHD

: The method uses hydroxylamine to treat N-acetylation, which produces acetohydroxamic acid (AHA) . This AHA molecule then serves as a "reporter" that is specifically sensed by a modified protein nanopore (PBA-modified MspA). "NINAHD" (often stylized as ) refers to Nanopore