: Seattle Grace residents are forced to compete for surgeries and equipment with their new rivals. Tensions boil over when Reed Adamson attempts to take George O'Malley's old locker, leading to a confrontation with Izzie Stevens.
: Meredith Grey remains largely sidelined in a hospital bed throughout the episode, a creative choice made to accommodate actress Ellen Pompeo’s real-life maternity leave; the character is written as having just donated a portion of her liver to her father. Production and Impact [S6E5] Invasion
: This episode served as the first half of a crossover event with the spin-off Private Practice . The storyline of the patient Izzie endangered, Sarah Freemont, concludes in the Private Practice episode "Right Here, Right Now". : Seattle Grace residents are forced to compete