11282 Rar Page

The 2005 Cancer Research study (pages 11282–11286) shows that Akt phosphorylates and degrades the Pdcd4 tumor suppressor protein, which is critical for tumor progression. This mechanism is relevant to studies on Retinoic Acid Receptor (RAR) agonists, which can induce Pdcd4 expression to combat cancer. Read the study in the journal Cancer Research .