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Research has shown that transgender individuals, including those who identify as ladyboys, are disproportionately affected by HIV/AIDS. According to the World Health Organization (WHO), transgender women are 49 times more likely to acquire HIV compared to cisgender women.

One of the significant risk factors for HIV transmission among transgender individuals is unprotected anal sex. The anal mucosa is more fragile and prone to tears, which can increase the risk of HIV transmission.